お酒 is read as おさけ (osake) and means alcohol.
おさけ
osake
にほんしゅ
sake (rice wine)
さけ
alcohol
ささ
しゅ
ようしゅ
Western wine and spirits
いんしゅ
drinking alcohol
じざけ
local sake
しんしゅ
new brew of sake
びしゅ
high-grade sake
げんしゅ
refined sake not diluted in water
ききざけ
sake tasting
ちゅうごくしゅ
Chinese alcohol