酔い醒めの水下戸知らず
えいさめのみずげこしらず
a teetotaler doesn't know (how tasty) water is when waking up after having been drunk
上戸は毒を知らず下戸は薬を知らず is read as じょうごはどくをしらずげこはくすりをしらず (jougo ha doku o shirazugeko ha kusuri o shirazu) and means drinkers drink too much (and harm themselves in the process), nondrinkers drink too little (and miss out on the medicinal benefits of alcohol).
じょうごはどくをしらずげこはくすりをしらず
jougo ha doku o shirazugeko ha kusuri o shirazu
えいさめのみずげこしらず
a teetotaler doesn't know (how tasty) water is when waking up after having been drunk