上戸は毒を知らず下戸は薬を知らず
じょうごはどくをしらずげこはくすりをしらず
drinkers drink too much (and harm themselves in the process), nondrinkers drink too little (and miss out on the medicinal benefits of alcohol)
上戸 is read as じょうご (jougo) and means ... drinker (e.g. merry drinker, maudlin drinker).
じょうご
jougo
じょうごはどくをしらずげこはくすりをしらず
drinkers drink too much (and harm themselves in the process), nondrinkers drink too little (and miss out on the medicinal benefits of alcohol)