上戸は毒を知らず下戸は薬を知らず
じょうごはどくをしらずげこはくすりをしらず
drinkers drink too much (and harm themselves in the process), nondrinkers drink too little (and miss out on the medicinal benefits of alcohol)
酔い醒めの水下戸知らず is read as えいさめのみずげこしらず (eisamenomizugekoshirazu) and means a teetotaler doesn't know (how tasty) water is when waking up after having been drunk.
えいさめのみずげこしらず
eisamenomizugekoshirazu
じょうごはどくをしらずげこはくすりをしらず
drinkers drink too much (and harm themselves in the process), nondrinkers drink too little (and miss out on the medicinal benefits of alcohol)